Price range: $268.00 through $328.00
Background:
Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L (SELL; MIM 153240) (summary by Weinreich et al., 2009 [PubMed 19592277]).[supplied by OMIM, Feb 2011],
| Size | 50μL/100μL |
| Target | KLF2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 38kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human KLF2 AA range: 196-246 |
| Specificity | This antibody detects endogenous levels of KLF2 at Human/Mouse/Rat |
| Gene Name | KLF2 LKLF |
| Protein Name | KLF2 |
| Other Name | Krueppel-like factor 2; / Lung krueppel-like factor |
| Species | Human |
| Gene ID | 10365 |
| Uniprot | Q9Y5W3, |
| Species.1 | Mouse |
| Gene ID.1 | 16598 |
| Uniprot.1 | Q60843, |
| Species.2 | Rat |
| Gene ID.2 | 306330 |
| Uniprot.2 | Q9ET58 |
| Cellular Localization | Nucleus . |
| Tissue Expression | Brain,Hair follicle dermal papilla,Lung,Spleen, |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Apelin signaling pathway;Environmental Information Processing >> Signal transduction >> FoxO signaling pathway |
| Research Areas | >>FoxO signaling pathway; / >>Apelin signaling pathway; / >>Fluid shear stress and atherosclerosis |
| Function | Function:Binds to the CACCC box in the beta-globin gene promoter and activates transcription.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,subunit:Interacts with WWP1., |
