Name: Ksr2 Polyclonal Antibody
SKU: WP12946
Price: 268 USD
Availability: InStock

Ksr2 Polyclonal Antibody

Ucallm_WP12946-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP12946-100

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Product details

Background:

domain:The protein kinase domain is predicted to be catalytically inactive., function:Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production., PTM:Phosphorylated on Ser-474 by MARK3., similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family., similarity:Contains 1 phorbol-ester/DAG-type zinc finger., similarity:Contains 1 protein kinase domain., subunit:Interacts with MAP2K1, MAP3K8, MAPK, RAS and RAF., tissue specificity:Mainly expressed in brain and kidney.,

Specifications

Size	50μL/100μL
Target	Ksr2
Reactivity	Human, Mouse
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	108kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human KSR2. AA range:671-720
Specificity	Ksr2 Polyclonal Antibody detects endogenous levels of Ksr2 protein.
Gene Name	KSR2
Protein Name	Kinase suppressor of Ras 2
Other Name	KSR2; / Kinase suppressor of Ras 2; / hKSR2
Species	Human
Gene ID	283455
Uniprot	Q6VAB6,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q3UVC0
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm . Membrane; Peripheral membrane protein .
Tissue Expression	Mainly expressed in brain and kidney.
Signaling_pathway	Environmental Information Processing >> Signal transduction >> Ras signaling pathway
Research Areas	>>Ras signaling pathway
Function	Domain:The protein kinase domain is predicted to be catalytically inactive.,Function:Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.,PTM:Phosphorylated on Ser-474 by MARK3.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MAP2K1, MAP3K8, MAPK, RAS and RAF.,tissue specificity:Mainly expressed in brain and kidney.,