LC3A rabbit pAb
Ucallm_WP17800-50
Price range: $268.00 through $328.00
Product details
Background:
function:Probably involved in formation of autophagosomal vacuoles (autophagosomes)., PTM:The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II., similarity:Belongs to the MAP1 LC3 family., subcellular location:LC3-II binds to the autophagic membranes., subunit:3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins., tissue specificity:Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.,
Specifications
| Size | 50μL/100μL |
| Target | LC3A |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA, IHC |
| MW(Calculated) | 13kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human LC3A |
| Specificity | This antibody detects endogenous levels of Human LC3A |
| Gene Name | MAP1LC3A |
| Protein Name | LC3A |
| Other Name | Microtubule-associated proteins 1A/1B light chain 3A; / Autophagy-related protein LC3 A; / Autophagy-related ubiquitin-like modifier LC3 A; / MAP1 light chain 3-like protein 1; / MAP1A/MAP1B light chain 3 A; / MAP1A/MAP1B LC3 A; / Microtubule-associated protein 1 light chain 3 alpha |
| Species | Human |
| Gene ID | 84557 |
| Uniprot | Q9H492, |
| Species.1 | Mouse |
| Gene ID.1 | 66734 |
| Uniprot.1 | Q91VR7, |
| Species.2 | Rat |
| Gene ID.2 | 362245 |
| Uniprot.2 | Q6XVN8 |
| Cellular Localization | Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor . Endomembrane system; Lipid-anchor . Cytoplasm, cytoskeleton . LC3-II binds to the autophagic membranes. . |
| Tissue Expression | Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Autophagy - animal;Cellular Processes >> Transport and catabolism >> Mitophagy - animal;Cellular Processes >> Cell growth and death >> Ferroptosis;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway |
| Research Areas | >>Mitophagy - animal; / >>Autophagy - animal; / >>Ferroptosis; / >>Apelin signaling pathway; / >>NOD-like receptor signaling pathway; / >>Amyotrophic lateral sclerosis; / >>Pathways of neurodegeneration - multiple diseases; / >>Shigellosis; / >>Kaposi sarcoma-associated herpesvirus infection |
| Function | autophagic vacuole formation, proteolysis, autophagy, vacuole organization, macromolecule catabolic process, cellular response to starvation, response to extracellular stimulus, macroautophagy, modification-dependent protein catabolic process, protein catabolic process, response to nutrient levels, cellular response to extracellular stimulus, cellular response to nutrient levels, cellular response to stress, response to starvation, modification-dependent macromolecule catabolic process, cellular protein catabolic process, cellular macromolecule catabolic process,proteolysis involved in cellular protein catabolic process, |
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