LDOC1 Polyclonal Antibody
Ucallm_WP12990-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | LDOC1 |
| Reactivity | Human, Mouse |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 17kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LDOC1. AA range:21-70 |
| Specificity | LDOC1 Polyclonal Antibody detects endogenous levels of LDOC1 protein. |
| Gene Name | LDOC1 |
| Protein Name | Protein LDOC1 |
| Other Name | LDOC1; / BCUR1; / Protein LDOC1; / Leucine zipper protein down-regulated in cancer cells |
| Species | Human |
| Gene ID | 23641 |
| Uniprot | O95751, |
| Species.1 | Mouse |
| Gene ID.1 | 434784 |
| Uniprot.1 | Q7TPY9 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Ubiquitously expressed with high levels in brain ant thyroid and low expression in placenta, liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:May have an important role in the development and/or progression of some cancers.,similarity:Belongs to the LDOC1 family.,tissue specificity:Ubiquitously expressed with high levels in brain ant thyroid and low expression in placenta, liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined., |
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