Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is involved in generating and maintaining the asymmetric distribution of channels and receptors at the cell membrane. The encoded protein also is required for the localization of some specific channels and can be part of a protein complex that couples synaptic vesicle exocytosis to cell adhesion in the brain. [provided by RefSeq, May 2016],
| Size | 50μL/100μL |
| Target | LIN7A |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 25kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 10-90 |
| Specificity | LIN7A Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | LIN7A MALS1 VELI1 |
| Protein Name | Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1) |
| Other Name | |
| Species | Human |
| Gene ID | 8825 |
| Uniprot | O14910, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8JZS0, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q9Z250 |
| Cellular Localization | Cell membrane; Peripheral membrane protein . Basolateral cell membrane; Peripheral membrane protein . Cell junction . Cell junction, synapse, postsynaptic density membrane; Peripheral membrane protein . Cell junction, tight junction . Mainly basolateral in renal epithelial cells. . |
| Tissue Expression | Expressed in brain, testis, kidney, placenta and liver. |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.,Domain:The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.,Domain:The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.,Function:Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.,similarity:Belongs to the lin-7 family.,similarity:Contains 1 L27 domain.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells.,subunit:Forms two exclusive ternary complexes with CASK and APBA1 or CASKIN1 (By similarity). Can also interact with other modular proteins containing protein-protein interaction domains like MPP5, MPP6, MPP7, DLG1, DLG2 and DLG3 through its L27 domain. Interacts with DLG4, GRIN2B and MARCH11 as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The association of LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains. Associates with KIF17 via APBA1. Interacts with HTR4 (By similarity). Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C).,tissue specificity:Expressed in brain, testis, kidney, placenta and liver., |
