Price range: $268.00 through $328.00
Background:
This gene encodes an activating member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein is predominantly expressed in B cells, interacts with major histocompatibility complex class I ligands, and contributes to the regulation of immune responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013],
| Size | 50μL/100μL |
| Target | LIRA1 |
| Reactivity | Human |
| Applications | WB, IHC, IF |
| MW(Calculated) | |
| MW(Observed) | 53kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300; IF 1:200-1:1000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LILRA1. AA range:53-102 |
| Specificity | LIR-6 Polyclonal Antibody detects endogenous levels of LIR-6 protein. |
| Gene Name | LILRA1 LIR6 |
| Protein Name | Leukocyte immunoglobulin-like receptor subfamily A member 1 |
| Other Name | LILRA1; / LIR6; / Leukocyte immunoglobulin-like receptor subfamily A member 1; / CD85 antigen-like family member I; / Leukocyte immunoglobulin-like receptor 6; / LIR-6; / CD antigen CD85i |
| Species | Human |
| Gene ID | 11024 |
| Uniprot | O75019 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Single-pass type I membrane protein. |
| Tissue Expression | Detected in monocytes and B-cells. |
| Signaling_pathway | Organismal Systems >> Immune system >> B cell receptor signaling pathway;Organismal Systems >> Development and regeneration >> Osteoclast differentiation |
| Research Areas | >>Osteoclast differentiation; / >>B cell receptor signaling pathway |
| Function | Function:May act as receptor for class I MHC antigens.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Detected in monocytes and B-cells., |
