LPL Monoclonal Antibody
Ucallm_WM0302-50
Price range: $268.00 through $328.00
Product details
Background:
lipoprotein lipase(LPL) Homo sapiens LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | LPL |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | 53kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 13D2 |
| Immunogen | Purified recombinant fragment of LPL expressed in E. Coli. |
| Specificity | LPL Monoclonal Antibody detects endogenous levels of LPL protein. |
| Gene Name | LPL |
| Protein Name | Lipoprotein lipase |
| Other Name | LPL; / LIPD; / Lipoprotein lipase; / LPL |
| Species | Human |
| Gene ID | 4023 |
| Uniprot | P06858, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P11152 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Peripheral membrane protein; Extracellular side . Secreted . Secreted, extracellular space, extracellular matrix . Newly synthesized LPL binds to cell surface heparan proteoglycans and is then released by heparanase. Subsequently, it becomes attached to heparan proteoglycan on endothelial cells (PubMed:27811232). Locates to the plasma membrane of microvilli of hepatocytes with triglyceride-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles (By similarity). . |
| Tissue Expression | Detected in blood plasma (PubMed:2340307, PubMed:11893776, PubMed:12641539). Detected in milk (at protein level) (PubMed:2340307). |
| Signaling_pathway | Organismal Systems >> Endocrine system >> PPAR signaling pathway;Human Diseases >> Neurodegenerative disease >> Alzheimer disease |
| Research Areas | >>Glycerolipid metabolism; / >>PPAR signaling pathway; / >>Cholesterol metabolism; / >>Alzheimer disease |
| Function | Catalytic activity:Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.,Disease:Defects in LPL are a cause of familial chylomicronemia [MIM:238600]; also known as hyperlipoproteinemia type I. Familial chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis.,Disease:Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency) [MIM:238600]. LPL deficiency leads to hypertriglyceridemia.,Function:The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). The enzyme functions in the presence of apolipoprotein C-2 on the luminal surface of vascular endothelium.,online information:Lipoprotein lipase entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the AB hydrolase superfamily. Lipase family.,similarity:Contains 1 PLAT domain.,subunit:Homodimer. Interacts with apolipoprotein C-2. Interacts with GPIHBP1., |
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