LWS Polyclonal Antibody
Ucallm_WP15982-50
Price range: $268.00 through $328.00
Product details
Background:
retinoid X receptor gamma(RXRG) Homo sapiens This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010],
Specifications
| Size | 50μL/100μL |
| Target | LWS |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 50kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:10000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human LWS. at AA range: 380-420 |
| Specificity | This antibody detects endogenous levels of LWS |
| Gene Name | RXRG NR2B3 |
| Protein Name | LWS |
| Other Name | Retinoic acid receptor RXR-gamma; / Nuclear receptor subfamily 2 group B member 3; / Retinoid X receptor gamma |
| Species | Human |
| Gene ID | 6258 |
| Uniprot | P48443, |
| Species.1 | Mouse |
| Gene ID.1 | 20183 |
| Uniprot.1 | P28705 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm . |
| Tissue Expression | Expressed in aortic endothelial cells (at protein level). |
| Signaling_pathway | Organismal Systems >> Immune system >> Th17 cell differentiation;Organismal Systems >> Endocrine system >> Adipocytokine signaling pathway;Organismal Systems >> Endocrine system >> PPAR signaling pathway;Organismal Systems >> Endocrine system >> Thyroid hormone signaling pathway;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: specific types >> Gastric cancer;Human Diseases >> Cancer: specific types >> Thyroid cancer;Human Diseases >> Cancer: specific types >> Small cell lung cancer;Human Diseases >> Cancer: specific types >> Non-small cell lung cancer |
| Research Areas | >>PPAR signaling pathway; / >>Th17 cell differentiation; / >>Thyroid hormone signaling pathway; / >>Adipocytokine signaling pathway; / >>Parathyroid hormone synthesis, secretion and action; / >>Pathways in cancer; / >>Transcriptional misregulation in cancer; / >>Chemical carcinogenesis - receptor activation; / >>Thyroid cancer; / >>Small cell lung cancer; / >>Non-small cell lung cancer; / >>Gastric cancer; / >>Lipid and atherosclerosis |
| Function | Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,Domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,Function:Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA).,similarity:Belongs to the nuclear hormone receptor family. NR2 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain., |
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