Name: U-Blot® LXRα Rabbit mAb
SKU: WR4613
Price: 268 USD
Availability: InStock

U-Blot® LXRα Rabbit mAb

Western Blot analysis using SH-SY5Y lysates,primary antibody was diluted at 1:1000, 4°over night, Dylight 800 secondary antibody(WS0446)was diluted at 1:10000, 37° 1hour.

WR4613 Western Blot analysis using SH-SY5Y lysates,primary antibody was diluted at 1:1000, 4°over night, Dylight 800 secondary antibody(WS0446)was diluted at 1:10000, 37° 1hour.

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WR4613-50

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Product details

Background:The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

Specifications

Size	50μL/100μL
Target	LXRα
Reactivity	Human, Mouse, Rat, Hamster
Applications	WB, IF, ELISA
MW(Calculated)	50kD
MW(Observed)	50kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM0887R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	NR1H3
Protein Name	Oxysterols receptor LXR-alpha
Other Name	NR1H3; / LXRA; / Oxysterols receptor LXR-alpha; / Liver X receptor alpha; / Nuclear receptor subfamily 1 group H member 3
Species	Human
Gene ID	10062
Uniprot	Q13133,
Species.1	Mouse
Gene ID.1	22259
Uniprot.1	Q9Z0Y9,
Species.2	Rat
Gene ID.2
Uniprot.2	Q62685
Cellular Localization	Nucleus . Cytoplasm .
Tissue Expression	Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.
Signaling_pathway	Organismal Systems >> Endocrine system >> PPAR signaling pathway
Research Areas	>>PPAR signaling pathway; / >>Insulin resistance; / >>Non-alcoholic fatty liver disease; / >>Hepatitis C
Function	Function:Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis.,induction:By 9-cis retinoic acid (9CRA).,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Heterodimer of LXRA and RXR.,tissue specificity:Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.,