M4K5 Polyclonal Antibody
Ucallm_WP2014-50
Price range: $268.00 through $328.00
Product details
Background:
mitogen-activated protein kinase kinase kinase kinase 5(MAP4K5) Homo sapiens This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | M4K5 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 93kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 300-380 |
| Specificity | M4K5 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | MAP4K5 |
| Protein Name | Mitogen-activated protein kinase kinase kinase kinase 5 (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) |
| Other Name | |
| Species | Human |
| Gene ID | 11183 |
| Uniprot | Q9Y4K4, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8BPM2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,Function:May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CNH domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with both SH3 domains of the adapter proteins CRK and CRKL.,tissue specificity:Ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate., |
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