Product details
Background:
MAEL rabbit pAb
Ucallm_WP7855-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | MAEL |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 48kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human MAEL |
| Specificity | This antibody detects endogenous levels of MAEL at Human, Mouse |
| Gene Name | MAEL |
| Protein Name | Protein maelstrom homolog |
| Other Name | |
| Species | Human |
| Gene ID | 84944 |
| Uniprot | Q96JY0, |
| Species.1 | Mouse |
| Gene ID.1 | 98558 |
| Uniprot.1 | Q8BVN9 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs (By similarity). . |
| Tissue Expression | Testis-specific. Expressed in various cancer cell lines, probably due to demethylation of its promoter. |
| Signaling_pathway | |
| Research Areas | |
| Function | Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity). |
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