MEK Kinase-2 Monoclonal Antibody
Ucallm_WM0313-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | MAP3K2 |
| Reactivity | Human |
| Applications | WB, IF, ELISA |
| MW(Calculated) | 70kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 6C10 |
| Immunogen | Purified recombinant fragment of human MEK Kinase-2 expressed in E. Coli. |
| Specificity | MEK Kinase-2 Monoclonal Antibody detects endogenous levels of MEK Kinase-2 protein. |
| Gene Name | MAP3K2 MAPKKK2 MEKK2 |
| Protein Name | Mitogen-activated protein kinase kinase kinase 2 |
| Other Name | MEK kinase 2; / MAP3K2; / MAPKKK2; / MEKK2; / Mitogen-activated protein kinase kinase kinase 2; / MAPK/ERK kinase kinase 2; / MEKK 2 |
| Species | Human |
| Gene ID | 10746 |
| Uniprot | Q9Y2U5, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q61083 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . Upon EGF stimulation, translocates into the nucleus. |
| Tissue Expression | Brain,Platelet,T-cell,Teratocarcinoma,Whole embryo, |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Gap junction;Organismal Systems >> Endocrine system >> GnRH signaling pathway;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>Gap junction; / >>GnRH signaling pathway |
| Function | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-524.,Function:Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 OPR domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Upon EGF stimulation, translocates into the nucleus.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes., |
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