Product details
Background:
MFSD2 rabbit pAb
Ucallm_WP8981-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | MFSD2A |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 60kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human MFSD2 |
| Specificity | This antibody detects endogenous levels of MFSD2 at Human, Mouse |
| Gene Name | MFSD2A MFSD2 HMFN0656 PP9177 UNQ300/PRO341 |
| Protein Name | Major facilitator superfamily domain-containing protein 2A |
| Other Name | |
| Species | Human |
| Gene ID | 84879 |
| Uniprot | Q8NA29, |
| Species.1 | Mouse |
| Gene ID.1 | 76574 |
| Uniprot.1 | Q9DA75 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Endoplasmic reticulum membrane; Multi-pass membrane protein . Cytoplasmic punctae that may represent vesicles shuttling between the endoplasmic reticulum and the plasma membrane (PubMed:21677192). . |
| Tissue Expression | In placenta, associated with trophoblast cells. |
| Signaling_pathway | |
| Research Areas | |
| Function | Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function . Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain . Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity). Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity). Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation . In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion . |
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