MIPP Polyclonal Antibody
Ucallm_WP13174-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2, 3 bisphosphoglycerate (2, 3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2, 3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009],
Specifications
| Size | 50μL/100μL |
| Target | MIPP |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 60kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MINPP1. AA range:328-377 |
| Specificity | MIPP Polyclonal Antibody detects endogenous levels of MIPP protein. |
| Gene Name | MINPP1 |
| Protein Name | Multiple inositol polyphosphate phosphatase 1 |
| Other Name | MINPP1; / MIPP; / Multiple inositol polyphosphate phosphatase 1; / 2; / 3-bisphosphoglycerate 3-phosphatase; / 2,3-BPG phosphatase; / Inositol; / 1,3,4,5; / -tetrakisphosphate 3-phosphatase; / Ins; / 1,3,4,5; / P; / 4; / 3-phosphatase |
| Species | Human |
| Gene ID | 9562 |
| Uniprot | Q9UNW1, |
| Species.1 | Mouse |
| Gene ID.1 | 17330 |
| Uniprot.1 | Q9Z2L6, |
| Species.2 | Rat |
| Gene ID.2 | 29688 |
| Uniprot.2 | O35217 |
| Cellular Localization | Endoplasmic reticulum lumen . |
| Tissue Expression | Widely expressed with highest levels in kidney, liver and placenta. |
| Signaling_pathway | |
| Research Areas | >>Glycolysis / Gluconeogenesis; / >>Inositol phosphate metabolism; / >>Metabolic pathways |
| Function | Catalytic activity:Myo-inositol hexakisphosphate + H(2)O = myo-inositol pentakisphosphate (mixed isomers) + phosphate.,Disease:Defects in MINPP1 may be involved in follicular thyroid tumors development.,Function:Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) (By similarity). May play a role in bone development (endochondral ossification).,tissue specificity:Widely expressed with highest levels in kidney, liver and placenta., |
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