Price range: $268.00 through $328.00
Background:
Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
| Size | 50μL/100μL |
| Target | MK04 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 64kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 410-490 |
| Specificity | MK04 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | MAPK4 ERK4 PRKM4 |
| Protein Name | Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK) |
| Other Name | |
| Species | Human |
| Gene ID | 5596 |
| Uniprot | P31152, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q6P5G0, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q63454 |
| Cellular Localization | Cytoplasm . Nucleus . Translocates to the cytoplasm following interaction with MAPKAPK5. . |
| Tissue Expression | High expression in heart and brain. |
| Signaling_pathway | Organismal Systems >> Immune system >> IL-17 signaling pathway |
| Research Areas | >>IL-17 signaling pathway |
| Function | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,Function:Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:High expression in heart and brain., |
