MMP7 (Cleaved-Tyr95) rabbit pAb
Ucallm_WP0182-50
Price range: $268.00 through $328.00
Product details
Background:
catalytic activity:Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I)., cofactor:Binds 2 calcium ions per subunit., cofactor:Binds 2 zinc ions per subunit., domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme., function:Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase., similarity:Belongs to the peptidase M10A family.,
Specifications
| Size | 50μL/100μL |
| Target | MMP-7 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA, IHC |
| MW(Calculated) | |
| MW(Observed) | 19kD,29kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human MMP7 (Cleaved-Tyr95) |
| Specificity | This antibody detects endogenous levels of Human,Mouse,Rat MMP7 (Cleaved-Tyr95, protein was cleaved amino acid sequence between 94-95 ) |
| Gene Name | MMP7 MPSL1 PUMP1 |
| Protein Name | MMP7 (Cleaved-Tyr95) |
| Other Name | MMP7; / MPSL1; / PUMP1; / Matrilysin; / Matrin; / Matrix metalloproteinase-7; / MMP-7; / Pump-1 protease; / Uterine metalloproteinase |
| Species | Human |
| Gene ID | 4316 |
| Uniprot | P09237, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q10738, |
| Species.2 | Rat |
| Gene ID.2 | 25335 |
| Uniprot.2 | P50280 |
| Cellular Localization | Secreted, extracellular space, extracellular matrix . |
| Tissue Expression | |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Wnt signaling pathway |
| Research Areas | >>Wnt signaling pathway; / >>Human T-cell leukemia virus 1 infection |
| Function | proteolysis, collagen catabolic process, collagen metabolic process, regulation of cell proliferation, multicellular organismal metabolic process, multicellular organismal catabolic process, multicellular organismal macromolecule metabolic process, |
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