Price range: $268.00 through $328.00
Background:
The protein encoded by this gene has multiple PDZ domains, which are hallmarks of protein-protein interactions. The encoded protein is known to interact with the HTR2C receptor and may cause it to clump at the cell surface. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015],
| Size | 50μL/100μL |
| Target | MPDZ |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA, IHC |
| MW(Calculated) | 228kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human MPDZ AA range: 1564-1614 |
| Specificity | This antibody detects endogenous levels of MPDZ at Human/Mouse/Rat |
| Gene Name | MPDZ MUPP1 |
| Protein Name | MPDZ |
| Other Name | |
| Species | Human |
| Gene ID | 8777 |
| Uniprot | O75970, |
| Species.1 | Mouse |
| Gene ID.1 | 17475 |
| Uniprot.1 | Q8VBX6, |
| Species.2 | Rat |
| Gene ID.2 | 29365 |
| Uniprot.2 | O55164 |
| Cellular Localization | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic density. Cell projection, dendrite. Cell junction, tight junction. Cell junction, synapse. Cell junction, synapse, synaptosome. Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells (By similarity). Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR. . |
| Tissue Expression | Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Tight junction |
| Research Areas | >>Tight junction |
| Function | similarity:Contains 13 PDZ (DHR) domains., |
