Product details
Background:
RBM7 rabbit pAb
Ucallm_WP7540-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | RBM7 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 29kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RBM7 |
| Specificity | This antibody detects endogenous levels of RBM7 at Human, Mouse |
| Gene Name | RBM7 |
| Protein Name | RNA-binding protein 7 (RNA-binding motif protein 7) |
| Other Name | |
| Species | Human |
| Gene ID | 10179 |
| Uniprot | Q9Y580, |
| Species.1 | Mouse |
| Gene ID.1 | 67010 |
| Uniprot.1 | Q9CQT2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus, nucleoplasm . Nucleus . Excluded from the nucleolus. . |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | |
| Research Areas | |
| Function | RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation . NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs . Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs) . Participates in several biological processes including DNA damage response (DDR) and stress response . During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome . Participates in DNA damage response (DDR), through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability . |
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