Recombinant 4-1BBL/CD137L Fc-Fused Nanobody (VF0439)
Ucallm_WN0001
$365.00
Product details
Background:The protein encoded byThis gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family.This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes.This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded byThis gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation.This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells.This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided b
Specifications
| Size | 100μL |
| Target | 4-1BBL/CD137L |
| Reactivity | Human |
| Applications | ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000 |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0056 |
| Immunogen | Purified recombinant Human 4-1BBL |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of 4-1BBL/CD137L protein. |
| Gene Name | TNFSF9 |
| Protein Name | Tumor necrosis factor ligand superfamily member 9 (4-1BB ligand) (4-1BBL) |
| Other Name | TNFSF9; / Tumor necrosis factor ligand superfamily member 9; / 4-1BB ligand; / 4-1BBL |
| Species | Human |
| Gene ID | 8744 |
| Uniprot | P41273 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Single-pass type II membrane protein. |
| Tissue Expression | |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction |
| Research Areas | |
| Function | Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer .,tissue specificity:Expressed in brain, placenta, lung, skeletal muscle and kidney., |
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