$365.00
Background:The Fc fragment of IgG receptor IIb encoded by FCGR2B is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations inThis gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found forThis gene.
| Size | 100μL |
| Target | CD32 |
| Reactivity | Human |
| Applications | ELISA, FC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000 |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0228 |
| Immunogen | Purified recombinant Human CD32 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD32 protein. |
| Gene Name | FCGR2B |
| Protein Name | Low affinity immunoglobulin gamma Fc region receptor II-b |
| Other Name | CD32 antibody; / CD32 antigen antibody; / CD32B antibody; / CDw32 antibody; / Fc fragment of IgG; / low affinity II; / receptor for; / CD32; / antibody; / Fc fragment of IgG; / low affinity IIb; / receptor antibody; / Fc fragment of IgG; / low affinity IIb; / receptor; / CD32; / antibody; / Fc fragment of IgG; / low affinity IIb; / receptor for; / CD32; / antibody; / Fc fragment of IgG; / low affinity IIb; / receptor for antibody; / Fc gamma receptor IIB antibody; / Fc gamma RII antibody; / Fc gamma RIIB antibody; / Fc-gamma RII antibody; / Fc-gamma RII-b antibody; / Fc-gamma-RIIb antibody; / FCG2 antibody; / FCG2B_HUMAN antibody; / Fcgr2 antibody; / FCGR2B antibody; / FCRII antibody; / FcRII-b antibody; / IGFR2 antibody; / IgG Fc receptor II beta antibody; / IgG Fc receptor II-b antibody; / Low affinity immunoglobulin gamma Fc region receptor II antibody; / Low affinity immunoglobulin gamma Fc region receptor II-b antibody; / Ly-17 antibody; / Lym 1 antibody; / Lymphocyte antigen 17 antibody; / CD32 nanobody |
| Species | Human |
| Gene ID | 2213 |
| Uniprot | P31994 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Tissue Expression | Detected in platelets (at protein level) (PubMed:1964571). Expressed by a variety of hematopoietic and epithelial cells (PubMed:1964571). |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Immune system >> B cell receptor signaling pathway;Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis;Organismal Systems >> Development and regeneration >> Osteoclast differentiation |
| Research Areas | |
| Function | Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion.,PTM:Protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids.,similarity:Belongs to the tetraspanin (TM4SF) family.,subunit:Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Associates with CR2/CD21 and with PTGFRN/CD9P1. Interacts directly with IGSF8.,tissue specificity:Expressed by a variety of hematopoietic and epithelial cells., |
