$365.00
Background:The protein encoded byThis gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects inThis gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found forThis gene.[provided by RefSeq, Mar 2011]
| Size | 100μL |
| Target | CD73 |
| Reactivity | Human |
| Applications | ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000; Flow Cyt 1-2μg/Test |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0548 |
| Immunogen | Purified recombinant Human CD73 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD73 protein. |
| Gene Name | NT5E NT5 NTE |
| Protein Name | 5'-nucleotidase (5'-NT) (Ecto-5'-nucleotidase) (CD antigen CD73) |
| Other Name | NT5E; / NT5; / NTE; / 5'-nucleotidase; / 5'-NT; / Ecto-5'-nucleotidase; / CD antigen CD73; / CD73 nanobody |
| Species | Human |
| Gene ID | 4907 |
| Uniprot | P21589 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Lipid-anchor, GPI-anchor . |
| Tissue Expression | Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.,cofactor:Zinc.,Disease:There is a decrease in the activity of NT5 in B-cell chronic lymphocytic leukemia.,Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.,similarity:Belongs to the 5'-nucleotidase family.,subunit:Homodimer; disulfide-linked., |
