Rev-erbα Polyclonal Antibody
Ucallm_WP14259-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013],
Specifications
| Size | 50μL/100μL |
| Target | NR1D1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| MW(Calculated) | |
| MW(Observed) | 67kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from Rev-erbα . at AA range: 350-430 |
| Specificity | Rev-erbα Polyclonal Antibody detects endogenous levels of Rev-erbα protein. |
| Gene Name | NR1D1 |
| Protein Name | Nuclear receptor subfamily 1 group D member 1 |
| Other Name | NR1D1; / EAR1; / HREV; / THRAL; / Nuclear receptor subfamily 1 group D member 1; / Rev-erbA-alpha; / V-erbA-related protein 1; / EAR-1 |
| Species | Human |
| Gene ID | 9572 |
| Uniprot | P20393, |
| Species.1 | Mouse |
| Gene ID.1 | 217166 |
| Uniprot.1 | Q3UV55, |
| Species.2 | Rat |
| Gene ID.2 | 252917 |
| Uniprot.2 | Q63503 |
| Cellular Localization | Nucleus . Cytoplasm . Cell projection, dendrite . Cell projection, dendritic spine . Localizes to the cytoplasm, dendrites and dendritic spine in the presence of OPHN1. Localizes predominantly to the nucleus at ZT8 whereas it is cytoplasmic at ZT20. Phosphorylation by CSNK1E enhances its cytoplasmic localization. . |
| Tissue Expression | Widely expressed. Expressed at high levels in the liver, adipose tissue, skeletal muscle and brain. Also expressed in endothelial cells (ECs), vascular smooth muscle cells (VSMCs) and macrophages. Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues. Expression increases during the differentiation of pre-adipocytes into mature adipocytes. Expressed at high levels in some squamous carcinoma cell lines. |
| Signaling_pathway | Organismal Systems >> Environmental adaptation >> Circadian rhythm |
| Research Areas | >>Circadian rhythm |
| Function | Domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,Function:Functions as a constitutive transcriptional repressor. Possible receptor for triiodothyronine.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Interacts with C1D.,tissue specificity:Expressed in all tissues and cell lines examined. Expressed at high levels in some squamous carcinoma cell lines., |
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