RGS1 Polyclonal Antibody
Ucallm_WP14271-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | RGS1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 22kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RGS1. AA range:118-167 |
| Specificity | RGS1 Polyclonal Antibody detects endogenous levels of RGS1 protein. |
| Gene Name | RGS1 |
| Protein Name | Regulator of G-protein signaling 1 |
| Other Name | RGS1; / 1R20; / BL34; / IER1; / Regulator of G-protein signaling 1; / RGS1; / B-cell activation protein BL34; / Early response protein 1R20 |
| Species | Human |
| Gene ID | 5996 |
| Uniprot | Q08116, |
| Species.1 | Mouse |
| Gene ID.1 | 50778 |
| Uniprot.1 | Q9JL25, |
| Species.2 | Rat |
| Gene ID.2 | 54289 |
| Uniprot.2 | P97844 |
| Cellular Localization | Cell membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasm, cytosol . |
| Tissue Expression | Detected in peripheral blood monocytes (PubMed:10480894). Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high (PubMed:8473738). |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation.,induction:In response to several B-cell activation signals.,PTM:Could be phosphorylated. Might be functionally regulated by protein kinase(s).,similarity:Contains 1 RGS domain.,tissue specificity:B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin's lymphoma and hairy cell leukemia, expression is constitutively high., |
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