Product details
Background:
RIC3 rabbit pAb
Ucallm_WP7287-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | RIC3 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 41kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RIC3 |
| Specificity | This antibody detects endogenous levels of RIC3 at Human, Mouse |
| Gene Name | RIC3 UNQ720/PRO1385 |
| Protein Name | Protein RIC-3 |
| Other Name | |
| Species | Human |
| Gene ID | 79608 |
| Uniprot | Q7Z5B4, |
| Species.1 | Mouse |
| Gene ID.1 | 320360 |
| Uniprot.1 | Q8BPM6 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 1]: Endoplasmic reticulum membrane; Single-pass membrane protein.; [Isoform 2]: Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. |
| Tissue Expression | Broadly expressed, with high levels in muscle, brain, heart, pancreas and testis. In the central nervous system, highest levels are detected in the cerebellum and pituitary gland. Over-expressed in brains from patients with bipolar disease or schizophrenia. Isoform 5 is predominantly expressed in the brain. |
| Signaling_pathway | |
| Research Areas | |
| Function | Molecular chaperone which facilitates proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors . May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4. |
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