Product details
Background:
RING1 rabbit pAb
Ucallm_WP8687-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | RING1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 45kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RING1 |
| Specificity | This antibody detects endogenous levels of RING1 at Human, Mouse,Rat |
| Gene Name | RING1 RNF1 |
| Protein Name | E3 ubiquitin-protein ligase RING1 (Polycomb complex protein RING1) (RING finger protein 1) (Really interesting new gene 1 protein) |
| Other Name | |
| Species | Human |
| Gene ID | 6015 |
| Uniprot | Q06587, |
| Species.1 | Mouse |
| Gene ID.1 | 19763 |
| Uniprot.1 | O35730, |
| Species.2 | Rat |
| Gene ID.2 | 309626 |
| Uniprot.2 | Q6MGB6 |
| Cellular Localization | Nucleus . Nucleus speckle . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. |
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