Price range: $268.00 through $328.00
Background:
This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension. [provided by RefSeq, Apr 2014],
| Size | 50μL/100μL |
| Target | RND1 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 25kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 140-220 |
| Specificity | RND1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | RND1 RHO6 |
| Protein Name | Rho-related GTP-binding protein Rho6 (Rho family GTPase 1) (Rnd1) |
| Other Name | |
| Species | Human |
| Gene ID | 27289 |
| Uniprot | Q92730, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8BLR7 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Lipid-anchor; Cytoplasmic side . Cytoplasm, cytoskeleton . |
| Tissue Expression | Mostly expressed in brain and liver. |
| Signaling_pathway | |
| Research Areas | >>Axon guidance |
| Function | Function:Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.,similarity:Belongs to the small GTPase superfamily. Rho family.,subunit:Binds GRB7 and PLXNB1. Interacts with UBXD5.,tissue specificity:Mostly expressed in brain and liver., |
