Price range: $268.00 through $328.00
Background:
The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | RNF5 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 19kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | RNF5 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | RNF5 G16 NG2 RMA1 |
| Protein Name | E3 ubiquitin-protein ligase RNF5 (Protein G16) (RING finger protein 5) (Ram1 homolog) (HsRma1) |
| Other Name | |
| Species | Human |
| Gene ID | 6048 |
| Uniprot | Q99942, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O35445, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q5M807 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Mitochondrion membrane; Multi-pass membrane protein . Endoplasmic reticulum membrane; Multi-pass membrane protein . Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles. . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | |
| Research Areas | >>Protein processing in endoplasmic reticulum |
| Function | Function:Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.,subunit:Interacts with PXN. Interacts with Salmonella typhimurium sopA. Interacts with JAMP.,tissue specificity:Widely expressed., |
