Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage. [provided by RefSeq, Nov 2014],
| Size | 50μL/100μL |
| Target | ROMO1 |
| Reactivity | Human, Mouse |
| Applications | IHC, IF |
| MW(Calculated) | 9kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-200; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ROMO1 AA range: 17-67 |
| Specificity | This antibody detects endogenous levels of ROMO1 at Human/Mouse |
| Gene Name | ROMO1 C20orf52 |
| Protein Name | ROMO1 |
| Other Name | |
| Species | Human |
| Gene ID | 140823 |
| Uniprot | P60602, |
| Species.1 | Mouse |
| Gene ID.1 | 67067 |
| Uniprot.1 | P60603 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Mitochondrion inner membrane; Single-pass membrane protein . |
| Tissue Expression | Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell line. Highly expressed in brain tumors. |
| Signaling_pathway | |
| Research Areas | |
| Function | developmental stage:Expression increases in senescent cells.,Function:Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence.,induction:By the anticancer drug fluorouracil (5FU).,miscellaneous:Enforced expression in IMR-90 cells leads to increased levels of ROS and induces premature cell senescence and nuclear DNA damage.,similarity:Belongs to the MGR2 family.,tissue specificity:Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell line., |
