RS17 Polyclonal Antibody
Ucallm_WP0790-50
Price range: $268.00 through $328.00
Product details
Background:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17E family of ribosomal proteins and is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia 4. Alternative splicing of this gene results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Apr 2014],
Specifications
| Size | 50μL/100μL |
| Target | RS17 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 14kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 30-110 |
| Specificity | RS17 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | RPS17 |
| Protein Name | 40S ribosomal protein S17 |
| Other Name | |
| Species | Human |
| Gene ID | 100505503 |
| Uniprot | P08708, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P63276, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P04644 |
| Cellular Localization | nucleoplasm,cytosol,ribosome,focal adhesion,membrane,cytosolic small ribosomal subunit,extracellular matrix,extracellular exosome, |
| Tissue Expression | B-cell,Kidney,Lung,Pancreas,Placenta,Prostate,Salivary gland, |
| Signaling_pathway | |
| Research Areas | >>Ribosome; / >>Coronavirus disease - COVID-19 |
| Function | Disease:Defects in RPS17 are the cause of Diamond-Blackfan anemia type 4 (DBA4) [MIM:612527]. DBA4 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.,similarity:Belongs to the ribosomal protein S17e family., |
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