Need Help? +(1)-866-986-9598
0 My Cart$0.00
Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/RSK2 rabbit pAb
SKU: WP17843 Categories: ,

RSK2 rabbit pAb

Ucallm_WP17843-50

Price range: $268.00 through $328.00

SKU: WP17843-100
Enter the quantity you would like, or drag the panel to find the quantity and price that best for you
Bulk QuoteAuthorize OEM & ODM

Product details

Background:

ribosomal protein S6 kinase A3(RPS6KA3) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetRSK2
ReactivityHuman, Mouse, Rat
ApplicationsWB
MW(Calculated)81kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human RSK2
SpecificityThis antibody detects endogenous levels of RSK2 at Human, Mouse,Rat
Gene NameRPS6KA3 ISPK1 MAPKAPK1B RSK2
Protein NameRSK2
Other NameRibosomal protein S6 kinase alpha-3; / S6K-alpha-3; / 90 kDa ribosomal protein S6 kinase 3; / p90-RSK 3; / p90RSK3; / Insulin-stimulated protein kinase 1; / ISPK-1; / MAP kinase-activated protein kinase 1b; / MAPK-activated protein kinase 1b; / MAPKAP kinase 1b; / MAPKAPK-1b; / Ribosomal S6 kinase 2; / RSK-2; / pp90RSK2
SpeciesHuman
Gene ID6197
UniprotP51812,
Species.1Mouse
Gene ID.1110651
Uniprot.1P18654
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus . Cytoplasm .
Tissue ExpressionExpressed in many tissues, highest levels in skeletal muscle.
Signaling_pathwayOrganismal Systems >> Nervous system >> Neurotrophin signaling pathway;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
Research Areas>>MAPK signaling pathway; / >>Oocyte meiosis; / >>mTOR signaling pathway; / >>Thermogenesis; / >>Long-term potentiation; / >>Neurotrophin signaling pathway; / >>Progesterone-mediated oocyte maturation; / >>Insulin resistance; / >>Yersinia infection; / >>Chemical carcinogenesis - receptor activation
FunctionCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,Disease:Defects in RPS6KA3 are the cause of Coffin-Lowry syndrome (CLS) [MIM:303600]; an X-linked dominant disorder characterized by severe mental retardation with facial and digital dysmorphisms, and progressive skeletal deformations.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,Function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-386, as part of the activation process.,PTM:Ser-227 phosphorylation promotes Ser-386 phosphorylation and leads to basal activation. Full activation by growth factors requires additional phosphorylation on Ser-369.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity). Interacts with NFATC4.,tissue specificity:Expressed in many tissues, highest levels in skeletal muscle.,
Please login to post questions

Related products

Western blot analysis of lysates from NIH-3T3 cells, using GCLM Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.
Sku: WR4015
Categories: ,

U-Blot® MMP7 Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options
Sku: WR4011
Categories: ,

U-Blot® Smad2 (Phospho Ser250) Rabbit mAb

0 Reviews
Price range: $288.00 through $368.00
Select options
Sku: WM1140
Categories: ,

Acetyl Lysine Monoclonal Antibody [10B10]

0 Reviews
Price range: $288.00 through $368.00
Select options
J774A.1 cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with primary antibody 1:1000. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody.
Sku: WR4006
Categories: ,

U-Blot® NLRP3 Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options
Sku: WR4008
Categories: ,

U-Blot® Hsp90 Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options
Sku: WR4018
Categories: ,

U-Blot® CDK6 Rabbit mAb

0 Reviews
Price range: $268.00 through $328.00
Select options

Customer Reviews

  • Shop Categories
Menu
Need Help? +(1)-866-986-9598
Back to Top
Product has been added to your cart