S-100 α Monoclonal Antibody
Ucallm_WM0411-50
Price range: $268.00 through $328.00
Product details
Background:
S100 calcium binding protein A1(S100A1) Homo sapiens The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | S100A1 |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 11kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 10A4 |
| Immunogen | Purified recombinant fragment of S-100 α expressed in E. Coli. |
| Specificity | S-100 α Monoclonal Antibody detects endogenous levels of S-100 α protein. |
| Gene Name | S100A1 |
| Protein Name | Protein S100-A1 |
| Other Name | S100A1; / S100A; / Protein S100-A1; / S-100 protein alpha chain; / S-100 protein subunit alpha; / S100 calcium-binding protein A1 |
| Species | Human |
| Gene ID | 6271 |
| Uniprot | P23297, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P56565 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Sarcoplasmic reticulum . Mitochondrion . |
| Tissue Expression | Highly prevalent in heart (PubMed:12804600, PubMed:1384693). Also found in lesser quantities in skeletal muscle and brain (PubMed:1384693). |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.,similarity:Belongs to the S-100 family.,similarity:Contains 2 EF-hand domains.,subunit:Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain.,tissue specificity:Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain., |
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