Product details
Background:
Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008],
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S5A1 Polyclonal Antibody
Ucallm_WP3289-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | S5A1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 28kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | S5A1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | SRD5A1 |
| Protein Name | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SR type 1) (Steroid 5-alpha-reductase 1) (S5AR 1) |
| Other Name | |
| Species | Human |
| Gene ID | 6715 |
| Uniprot | P18405, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q68FF9, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P24008 |
| Cellular Localization | Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein . |
| Tissue Expression | Liver and prostate (at a low level). |
| Signaling_pathway | |
| Research Areas | >>Steroid hormone biosynthesis; / >>Metabolic pathways |
| Function | Catalytic activity:A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-Delta(4)-steroid + reduced acceptor.,Function:Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.,induction:Its expression is regulated by androgens such as testosterone.,online information:5-alpha reductase entry,similarity:Belongs to the steroid 5-alpha reductase family.,tissue specificity:Liver and prostate (at a low level)., |
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