Price range: $268.00 through $328.00
Background:
The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008],
| Size | 50μL/100μL |
| Target | S61A2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 52kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human S61A2 AA range: 318-368 |
| Specificity | This antibody detects endogenous levels of S61A2 at Human/Mouse |
| Gene Name | SEC61A2 |
| Protein Name | S61A2 |
| Other Name | |
| Species | Human |
| Gene ID | 55176 |
| Uniprot | Q9H9S3, |
| Species.1 | Mouse |
| Gene ID.1 | 57743 |
| Uniprot.1 | Q9JLR1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein . |
| Tissue Expression | |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum |
| Research Areas | >>Protein export; / >>Protein processing in endoplasmic reticulum; / >>Phagosome; / >>Vibrio cholerae infection |
| Function | Function:Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins.,similarity:Belongs to the secY/SEC61-alpha family.,subunit:Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma., |
