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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/SIK2 Polyclonal Antibody
SKU: WP2291 Categories: ,

SIK2 Polyclonal Antibody

Ucallm_WP2291-50

Price range: $268.00 through $328.00

SKU: WP2291-100
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Product details

Background:

catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Activated by phosphorylation on Thr-175 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39., function:Phosphorylates ‘Ser-794’ of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators., similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 1 UBA domain., subunit:Interacts with and phosphorylates TORC2/CRTC2.,

Specifications

TargetQIK
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)101kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Source
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
Sequence
SpecificitySIK2 Polyclonal Antibody detects endogenous levels of protein.
Gene NameSIK2 KIAA0781 QIK SNF1LK2
Protein NameSerine/threonine-protein kinase SIK2 (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2)
Other NameSerine/threonine-protein kinase SIK2; / Qin-induced kinase; / Salt-inducible kinase 2; / SIK-2; / Serine/threonine-protein kinase SNF1-like kinase 2
SpeciesHuman
Gene ID-123235
UniprotQ9H0K1,
Species.1Mouse
Gene ID-2235344
Uniprot.1Q8CFH6
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Backgroundcatalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-175 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,function:Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA domain.,subunit:Interacts with and phosphorylates TORC2/CRTC2.,
Cellular LocalizationCytoplasm . Endoplasmic reticulum membrane .
Tissue ExpressionBrain,Colon,Lung,Testis,
Signaling_pathwayOrganismal Systems >> Endocrine system >> Glucagon signaling pathway
Research Areas>>Glucagon signaling pathway
FunctionCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-175 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,Function:Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA domain.,subunit:Interacts with and phosphorylates TORC2/CRTC2.,
RRID
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