SNX6 rabbit pAb
Ucallm_WP6824-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | SNX6 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 45kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SNX6 |
| Specificity | This antibody detects endogenous levels of SNX6 at Human, Mouse |
| Gene Name | SNX6 |
| Protein Name | Sorting nexin-6 (TRAF4-associated factor 2) |
| Other Name | |
| Species | Human |
| Gene ID | 58533 |
| Uniprot | Q9UNH7, |
| Species.1 | Mouse |
| Gene ID.1 | 72183 |
| Uniprot.1 | Q6P8X1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Early endosome . Early endosome membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasmic vesicle . Cytoplasm . Nucleus . Interaction with SNX1 or SNX2 promotes location at endosome membranes (PubMed:19935774). Only a minor proportion is seen in the nucleus. . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex . The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity . Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R . May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network . Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation . In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable). |
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