Product details
Background:
Sox9 is a transcription factor that plays a key role in chondrocyte differentiation and bone development. It is expressed in cartilage, neural crest, kidney and pancreas.
SOX9 [ABT-SOX9] mouse mAb
Ucallm_WM1448-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | Sox-9 |
| Reactivity | Human, Mouse, Rat, Bovine |
| Applications | IHC, WB, IF, ELISA |
| MW(Calculated) | 56kD |
| MW(Observed) | 70kD |
| Host Species | Mouse |
| Isotype | IgG2b,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM-SOX9 |
| Immunogen | Synthesized peptide derived from human SOX9 AA range: 1-100 |
| Specificity | The antibody can specifically recognize human SOX9 protein. In western blotting of SW480 and HepG2 cell lysates, the antibody can label a 60 kDa band corresponding to SOX9. |
| Gene Name | SOX9 |
| Protein Name | Transcription factor SOX-9 |
| Other Name | campomelic dysplasia autosomal sex reversal; / CMD 1; / CMD1; / CMPD 1; / CMPD1; / SOX 9; / Sox9; / SOX9_HUMAN; / SRA 1; / SRA1; / SRXX2; / SRXY10; / SRY; / sex determining region Y; / box 9; / campomelic dysplasia autosomal; / SRY; / sex determining region Y; / box 9; / SRY; / sex determining region Y; / -box 9; / SRY; / sex-determining region Y; / -box 9 protein; / SRY related HMG box gene 9; / Transcription factor SOX 9; / Transcription factor SOX-9; / transcription factor SOX9 |
| Species | Human |
| Gene ID | 6662 |
| Uniprot | P48436, |
| Species.1 | Mouse |
| Gene ID.1 | 20682 |
| Uniprot.1 | Q04887 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nuclear |
| Tissue Expression | Eye,PNS,Testis, |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> cAMP signaling pathway |
| Research Areas | >>cAMP signaling pathway |
| Function | Disease:Defects in SOX9 are the cause of campomelic dysplasia (CMD1) [MIM:114290]. CMD1 is a rare, often lethal, dominantly inherited, congenital osteochondrodysplasia, associated with male-to-female autosomal sex reversal in two-thirds of the affected karyotypic males. A disease of the newborn characterized by congenital bowing and angulation of long bones, unusually small scapulae, deformed pelvis and spine and a missing pair of ribs. Craniofacial defects such as cleft palate, micrognatia, flat face and hypertelorism are common. Various defects of the ear are often evident, affecting the cochlea, malleus incus, stapes and tympanum. Most patients die soon after birth due to respiratory distress which has been attributed to hypoplasia of the tracheobronchial cartilage and small thoracic cage.,Function:Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.,similarity:Contains 1 HMG box DNA-binding domain., |
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