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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/SPP2A rabbit pAb
SKU: WP17333 Categories: ,

SPP2A rabbit pAb

Ucallm_WP17333-50

Price range: $268.00 through $328.00

SKU: WP17333-100
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Product details

Background:

This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq, Feb 2012],

Specifications

Size50μL/100μL
TargetSPP2A
ReactivityHuman, Mouse
ApplicationsWB, IHC
MW(Calculated)57kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human SPP2A AA range: 66-116
SpecificityThis antibody detects endogenous levels of SPP2A at Human/Mouse
Gene NameSPPL2A IMP3 PSL2 PSEC0147
Protein NameSPP2A
Other Name
SpeciesHuman
Gene ID84888
UniprotQ8TCT8,
Species.1Mouse
Gene ID.166552
Uniprot.1Q9JJF9
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationLate endosome membrane; Multi-pass membrane protein . Lysosome membrane; Multi-pass membrane protein . Membrane; Multi-pass membrane protein; Lumenal side . Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane.
Tissue ExpressionUbiquitous.
Signaling_pathway
Research Areas
FunctionFunction:Functions as an intramembrane protease. Functions in ITM2B processing.,similarity:Belongs to the peptidase A22B family.,similarity:Contains 1 PA (protease associated) domain.,subunit:Interacts with ITM2B.,
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