SR-2A Polyclonal Antibody
Ucallm_WP14567-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],
Specifications
| Size | 50μL/100μL |
| Target | SR-2A |
| Reactivity | Human |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 53kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human 5-HT-2A. AA range:422-471 |
| Specificity | SR-2A Polyclonal Antibody detects endogenous levels of SR-2A protein. |
| Gene Name | HTR2A |
| Protein Name | 5-hydroxytryptamine receptor 2A |
| Other Name | HTR2A; / HTR2; / 5-hydroxytryptamine receptor 2A; / 5-HT-2; / 5-HT-2A; / Serotonin receptor 2A |
| Species | Human |
| Gene ID | 3356 |
| Uniprot | P28223, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P35363 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, axon . Cytoplasmic vesicle . Membrane, caveola . Cell junction, synapse, presynapse . |
| Tissue Expression | Detected in brain cortex (at protein level). Detected in blood platelets. |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Gap junction;Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway |
| Research Areas | >>Calcium signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Gap junction; / >>Serotonergic synapse; / >>Inflammatory mediator regulation of TRP channels |
| Function | Domain:The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1 and DLG4.,Function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production.,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Localizes to the post-synaptic thickening of axo-dendritic synapses.,subunit:Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2., |
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