SRGP2 rabbit pAb
Ucallm_WP16731-50
Price range: $268.00 through $328.00
Product details
Background:
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014],
Specifications
| Size | 50μL/100μL |
| Target | SRGP2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 118kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SRGP2 AA range: 476-526 |
| Specificity | This antibody detects endogenous levels of SRGP2 at Human/Mouse/Rat |
| Gene Name | SRGAP2 ARHGAP34 FNBP2 KIAA0456 SRGAP2A |
| Protein Name | SRGP2 |
| Other Name | |
| Species | Human |
| Gene ID | 23380 |
| Uniprot | O75044, |
| Species.1 | Mouse |
| Gene ID.1 | 14270 |
| Uniprot.1 | Q91Z67, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | D4A208 |
| Cellular Localization | Cell membrane . Cell projection, dendritic spine . Cell junction, synapse, postsynaptic density . Cell junction, synapse, postsynaptic cell membrane . Cell projection, lamellipodium . Cytoplasmic vesicle, phagosome . Nucleus . Cytoplasm, cytosol . Recruited to actin-rich phagosomes during phagocytosis (By similarity). Translocates from nucleus to cytoplasm during development (By similarity). . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | >>Axon guidance |
| Function | Function:Putative GTPase-activating protein for Rho family small GTPases.,similarity:Contains 1 FCH domain.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SH3 domain.,subunit:Probably interacts with ROBO1.,tissue specificity:Expression at low levels in placenta, kidney, and ovary, and little or no expression in all other tissues tested., |
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