SKU: WP14593 Categories: ,

SSTR1 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP14593-100
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Product details

Background:

Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012],

Specifications

Size50μL/100μL
TargetSSTR1
ReactivityHuman, Mouse, Rat, Monkey
ApplicationsWB, IF, ELISA
MW(Calculated)
MW(Observed)43kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human SSTR1. AA range:9-58
SpecificitySSTR1 Polyclonal Antibody detects endogenous levels of SSTR1 protein.
Gene NameSSTR1
Protein NameSomatostatin receptor type 1
Other NameSSTR1; / Somatostatin receptor type 1; / SS-1-R; / SS1-R; / SS1R; / SRIF-2
SpeciesHuman
Gene ID6751
UniprotP30872,
Species.1Mouse
Gene ID.120605
Uniprot.1P30873,
Species.2Rat
Gene ID.225033
Uniprot.2P28646
Cellular LocalizationCell membrane; Multi-pass membrane protein.
Tissue ExpressionFetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.
Signaling_pathwayOrganismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
Research Areas>>cAMP signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Growth hormone synthesis, secretion and action
FunctionFunction:Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with SKB1.,tissue specificity:Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.,
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