Name: SUMO4 Polyclonal Antibody
SKU: WP2309
Price: 268 USD
Availability: InStock

SUMO4 Polyclonal Antibody

Ucallm_WP2309-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP2309-100

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Product details

Background:

This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	SUMO4
Reactivity	Human
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	10kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from part region of human protein AA range: 1-50
Specificity	SUMO4 Polyclonal Antibody detects endogenous levels of protein.
Gene Name	SUMO4 SMT3H4
Protein Name	Small ubiquitin-related modifier 4 (SUMO-4) (Small ubiquitin-like protein 4)
Other Name
Species	Human
Gene ID	387082
Uniprot	Q6EEV6
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	nucleus,
Tissue Expression	Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues, with the highest expression in the lymph node and spleen.
Signaling_pathway	Genetic Information Processing >> Translation >> Nucleocytoplasmic transport
Research Areas	>>Nucleocytoplasmic transport; / >>Fluid shear stress and atherosclerosis
Function	Function:Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.,online information:SUMO protein entry,polymorphism:Variant Val-55 could be associated with insulin-dependent diabetes mellitus 5 (IDDM5) [MIM:600320].,PTM:In contrast to SUMO1, SUMO2 and SUMO3, seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates.,similarity:Belongs to the ubiquitin family. SUMO subfamily.,similarity:Contains 1 ubiquitin-like domain.,subunit:Interacts with SAE2. Covalently attached to a number of proteins.,tissue specificity:Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues, with the highest expression in the lymph node and spleen.,