Name: Synaptophysin [ABT533] mouse mAb
SKU: WM1449
Price: 268 USD
Availability: InStock

Synaptophysin [ABT533] mouse mAb

Ucallm_WM1449-50

Price range: $268.00 through $328.00

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50μl

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SKU: WM1449-50

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Product details

Background:
Synaptophysin is a 38 kDa membrane glycoprotein present in neuroendocrine cells. It is the most
abundant synaptic vessel membrane protein, but the function remains unclear. Synaptophysin is mainly expressed in neuroendocrine cells of the human adrenal medulla, carotid body, skin, pituitary,
thyroid, lung, pancreas, and gastrointestinal mucosa. The antibodiy is mainly used in the classification of neuroendocrine tumors including neoplasms of epithelial type, nervous system neoplasms with neuronal differentiation and adrenocortical neoplasms.

Specifications

Size	50μL/100μL
Target	Synaptophysin
Reactivity	Human, Mouse, Rat, Bovine
Applications	IHC, WB, IF, ELISA
MW(Calculated)	34kD
MW(Observed)	38kD
Host Species	Mouse
Isotype	IgG1,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RMM533
Immunogen	Synthesized peptide derived from human Synaptophysin AA range: 200-313
Specificity	The antibody can specifically recognize human Synaptophysin protein.
Gene Name	SYP
Protein Name	Major synaptic vesicle protein p38; MRX96; MRXSYP; Syn p38; Synaptophysin; Syp; SYPH; SYPH_HUMAN; SypI
Other Name	Major synaptic vesicle protein p38; / MRX96; / MRXSYP; / Syn p38; / Synaptophysin; / Syp; / SYPH; / SYPH_HUMAN; / SypI
Species	Human
Gene ID	6855
Uniprot	P08247,
Species.1	Mouse
Gene ID.1	20977
Uniprot.1	Q62277,
Species.2	Rat
Gene ID.2	24804
Uniprot.2	P07825
Cellular Localization	Cytoplasmic
Tissue Expression	Pancreas/ Colon
Signaling_pathway
Research Areas
Function	Domain:The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.,Function:Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane.,online information:Synaptophysin entry,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the synaptophysin/synaptobrevin family.,similarity:Contains 1 MARVEL domain.,subunit:Homohexamer or homotetramer.,tissue specificity:Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.,

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Synaptophysin [ABT533] mouse mAb

Product details

Specifications

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Synaptophysin [ABT533] mouse mAb

Product details

Specifications

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