SKU: WP14658 Categories: ,

T2R49 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP14658-100
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Product details

Background:

This gene encodes a member of the taste receptor two family of class C G-protein coupled receptors. Receptors of this family have a short extracellular N-terminus, seven transmembrane helices, three extracellular loops and three intracellular loops, and an intracellular C-terminus. Members of this family are expressed in a subset of taste receptor cells, where they function in bitter taste reception, as well as in non-gustatory cells including those of the brain, reproductive organs, respiratory system, and gastrointestinal system. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2016],

Specifications

Size50μL/100μL
TargetT2R49
ReactivityHuman
ApplicationsWB, IF, ELISA
MW(Calculated)
MW(Observed)38kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human TAS2R49. AA range:94-143
SpecificityT2R49 Polyclonal Antibody detects endogenous levels of T2R49 protein.
Gene NameTAS2R20
Protein NameTaste receptor type 2 member 20
Other NameTAS2R20; / TAS2R49; / Taste receptor type 2 member 20; / Taste receptor type 2 member 49; / T2R49; / Taste receptor type 2 member 56; / T2R56
SpeciesHuman
Gene ID259295
UniprotP59543
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembrane; Multi-pass membrane protein.
Tissue ExpressionExpressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
Signaling_pathway
Research Areas>>Taste transduction
FunctionFunction:Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.,miscellaneous:Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.,similarity:Belongs to the G-protein coupled receptor T2R family.,tissue specificity:Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.,
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