TAB1 [N-term] mouse mAb
Ucallm_WM0629-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced tr
Specifications
| Size | 50μL/100μL |
| Target | TAB1 |
| Reactivity | Human |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 55kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 6C11 |
| Immunogen | Purified recombinant human TAB1(N-terminus) protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of TAB1(N-terminus) and does not cross-react with related proteins. |
| Gene Name | TAB1 |
| Protein Name | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 |
| Other Name | 2310012M03Rik; / 3'-Tab1; / MAP3K7IP 1; / MAP3K7IP1; / MGC57664; / Mitogen activated protein kinase kinase kinase 7 interacting protein 1; / Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; / TAB 1; / TAB1; / TAB1_HUMAN; / TAK1 binding protein 1; / TAK1-binding protein 1; / TGF beta activated kinase 1 binding protein 1; / TGF-beta activated kinase 1/MAP3K7 binding protein 1; / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; / TGF-beta-activated kinase 1-binding protein 1; / Transforming growth factor beta activated kinase binding protein 1. |
| Species | Human |
| Gene ID | 10454 |
| Uniprot | Q15750 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | nucleoplasm,cytoplasm,cytosol,endosome membrane,protein complex, |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | Organismal Systems >> Immune system >> Toll-like receptor signaling pathway;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Development and regeneration >> Osteoclast differentiation;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway;Environmental Information Processing >> Signal transduction >> TNF signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>NF-kappa B signaling pathway; / >>Osteoclast differentiation; / >>Toll-like receptor signaling pathway; / >>NOD-like receptor signaling pathway; / >>TNF signaling pathway; / >>Alcoholic liver disease; / >>Pathogenic Escherichia coli infection; / >>Shigellosis; / >>Salmonella infection; / >>Yersinia infection; / >>Leishmaniasis; / >>Toxoplasmosis; / >>Hepatitis B; / >>Herpes simplex virus 1 infection; / >>Epstein-Barr virus infection; / >>Human immunodeficiency virus 1 infection; / >>Lipid and atherosclerosis |
| Function | Function:May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.,similarity:Contains 1 PP2C-like domain.,subunit:Interacts with MAP3K7, XIAP and BIRC7.,tissue specificity:Ubiquitous., |
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