Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | TAGLN |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 22kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TAGL Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | TAGLN SM22 WS3-10 |
| Protein Name | Transgelin (22 kDa actin-binding protein) (Protein WS3-10) (Smooth muscle protein 22-alpha) (SM22-alpha) |
| Other Name | |
| Species | Human |
| Gene ID | 6876 |
| Uniprot | Q01995, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P37804, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P31232 |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Aorta,Bone marrow,Brain,Fibroblast,Human small intestine,Peripheral blood,Uterus,White Matt |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.,induction:Overexpressed in senescent human fibroblasts.,similarity:Belongs to the calponin family.,similarity:Contains 1 calponin-like repeat.,similarity:Contains 1 CH (calponin-homology) domain., |
