TAT Polyclonal Antibody
Ucallm_WP14686-50
Price range: $268.00 through $328.00
Product details
Background:
This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | TAT |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 50kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TAT. AA range:255-304 |
| Specificity | TAT Polyclonal Antibody detects endogenous levels of TAT protein. |
| Gene Name | TAT |
| Protein Name | Tyrosine aminotransferase |
| Other Name | TAT; / Tyrosine aminotransferase; / TAT; / L-tyrosine:2-oxoglutarate aminotransferase |
| Species | Human |
| Gene ID | 6898 |
| Uniprot | P17735, |
| Species.1 | Mouse |
| Gene ID.1 | 234724 |
| Uniprot.1 | Q8QZR1, |
| Species.2 | Rat |
| Gene ID.2 | 24813 |
| Uniprot.2 | P04694 |
| Cellular Localization | mitochondrion,cytosol, |
| Tissue Expression | Liver, |
| Signaling_pathway | |
| Research Areas | >>Ubiquinone and other terpenoid-quinone biosynthesis; / >>Cysteine and methionine metabolism; / >>Tyrosine metabolism; / >>Phenylalanine metabolism; / >>Phenylalanine, tyrosine and tryptophan biosynthesis; / >>Metabolic pathways |
| Function | Catalytic activity:L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.,cofactor:Pyridoxal phosphate.,Disease:Defects in TAT are the cause of tyrosinemia type 2 (TYRO2) [MIM:276600]; also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation.,pathway:Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 2/6.,similarity:Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.,subunit:Homodimer., |
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