TGFβ RIII Polyclonal Antibody
Ucallm_WP14756-50
Price range: $268.00 through $328.00
Product details
Background:
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010],
Specifications
| Size | 50μL/100μL |
| Target | TGFβ RIII |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 93kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:500-2000; ELISA 1:5000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TGF beta Receptor III. AA range:801-850 |
| Specificity | TGFβ RIII Polyclonal Antibody detects endogenous levels of TGFβ RIII protein. |
| Gene Name | TGFBR3 |
| Protein Name | Transforming growth factor beta receptor type 3 |
| Other Name | TGFBR3; / Transforming growth factor beta receptor type 3; / TGF-beta receptor type 3; / TGFR-3; / Betaglycan; / Transforming growth factor beta receptor III; / TGF-beta receptor type III |
| Species | Human |
| Gene ID | 7049 |
| Uniprot | Q03167, |
| Species.1 | Mouse |
| Gene ID.1 | 21814 |
| Uniprot.1 | O88393, |
| Species.2 | Rat |
| Gene ID.2 | 29610 |
| Uniprot.2 | P26342 |
| Cellular Localization | Secreted. Secreted, extracellular space. Cell membrane; Single-pass type I membrane protein . Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix. |
| Tissue Expression | Blood,Brain,Placenta,Tongue, |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.,PTM:Extensively modified by glycosaminoglycan groups (GAG).,similarity:Contains 1 ZP domain.,subcellular location:Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.,subunit:Interacts with TCTEX1D4., |
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