Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010],
| Size | 50μL/100μL |
| Target | TIEG2 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 55kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human KLF11. AA range:1-50 |
| Specificity | TIEG2 Polyclonal Antibody detects endogenous levels of TIEG2 protein. |
| Gene Name | KLF11 |
| Protein Name | Krueppel-like factor 11 |
| Other Name | KLF11; / FKLF; / TIEG2; / Krueppel-like factor 11; / Transforming growth factor-beta-inducible early growth response protein 2; / TGFB-inducible early growth response protein 2; / TIEG-2 |
| Species | Human |
| Gene ID | 8462 |
| Uniprot | O14901, |
| Species.1 | Mouse |
| Gene ID.1 | 194655 |
| Uniprot.1 | Q8K1S5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Ubiquitous. Higher expression in erythroid cells. |
| Signaling_pathway | |
| Research Areas | |
| Function | Caution:PubMed:11087666 sequence was originally thought to originate from mouse.,Disease:Defects in KLF11 are the cause of maturity-onset diabetes of the young type 7 (MODY7) [MIM:610508]. MODY [MIM:606391] has an autosomal dominant inheritance, onset at age less than 25 years and a primary defect in insulin secretion. MODY pedigrees are usually multigenerational families with penetrance of 80 to 95%. Patients have a nonobese body habitus and the so-called metabolic syndrome characterized by diabetes, insulin resistance, hypertension, and hypertriglyceridemia is absent.,Function:Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.,induction:By TGF-beta.,similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,tissue specificity:Ubiquitous. Higher expression in erythroid cells., |
