Product details
Background:
TM4SF5 rabbit pAb
Ucallm_WP7755-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TM4SF5 |
| Reactivity | Human |
| Applications | WB |
| MW(Calculated) | 22kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TM4SF5 |
| Specificity | This antibody detects endogenous levels of TM4SF5 at Human |
| Gene Name | TM4SF5 |
| Protein Name | Transmembrane 4 L6 family member 5 (Tetraspan transmembrane protein L6H) |
| Other Name | |
| Species | Human |
| Gene ID | 9032 |
| Uniprot | O14894 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Lysosome membrane; Multi-pass membrane protein . Cell membrane; Multi-pass membrane protein . Localization to cell membrane increases during conditions of arginine depletion and translocation to lysosome membrane seen upon arginine repletion. . |
| Tissue Expression | Intestine. Overexpressed in pancreatic cancers. |
| Signaling_pathway | |
| Research Areas | |
| Function | Acts as a lysosomal membrane arginine sensor . Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations . Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus . CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression . |
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