Price range: $268.00 through $328.00
Background:
Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | TNNC2 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 17kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TNNC2 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | TNNC2 |
| Protein Name | Troponin C, skeletal muscle |
| Other Name | |
| Species | Human |
| Gene ID | 7125 |
| Uniprot | P02585, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P20801 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | cytosol,troponin complex, |
| Tissue Expression | Liver,Muscle,Skeletal muscle,Tongue, |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Calcium signaling pathway |
| Research Areas | >>Calcium signaling pathway |
| Function | Function:Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.,miscellaneous:Skeletal muscle troponin C binds four calcium ions.,similarity:Belongs to the troponin C family.,similarity:Contains 4 EF-hand domains., |
